EYLEA
AFLIBERCEPT · by BAYER
Composition
Inj: Per ml: Aflibercet 40 mg, solution for injection.
Indications & Dosage
Neovascular (wet) age-related macular degeneration: BY INTRAVITREAL INJ: Adult: Initially 2 mg once a month for 3 months, then 2 mg every 2 months, review treatment frequency after 12 months. Macular oedema secondary to retinal vein occlusion: BY INTRAVITREAL INJ: Adult: Initially 2 mg once a month until max. visual acuity is achieved or there are no signs of disease activity (discontinue treatment if no improvement in visual and anatomic outcomes). Diabetic macular oedema: BY INTRAVITREAL INJ: Adult: Initially 2 mg once a month for 5 months, then maintenance 2 mg every 2 months, review treatment frequency after 12 months (discontinue treatment if no improvement in visual and anatomic outcomes). Myopic choroidal neovascularisation: BY INTRAVITREAL INJ: Adult: 2 mg for 1 dose, if visual or anatomic outcomes indicate that disease persists, additional doses may be administered; the interval between 2 doses should be greater than 1 month.
Contraindications
Ocular or periocular infection, severe intra-ocular inflammation, irreversible ischaemic visual function loss CAUTIONS: Diabetic patients with uncontrolled hypertension, active systemic infection, discontinue treatment if stage 3 or 4 macular holes develop or in the event of a retinal break or rhegmatogenous retinal detachment (consult product literature for full details), patients at risk of retinal pigment epithelial tear, poorly controlled glaucoma, recent history of myocardial infarction, stroke or transient ischaemic attack. Monitor intra-ocular pressure following injection.
Interactions
Verteporfin
Pregnancy
Avoid unless potential benefit outweighs risk
Lactation
Contraindicated, discontinue breast feeding.
Side Effects
Cataract formation, corneal abrasion, oedema or haemorrhage, conjunctival hyperaemia, eye pain, eyelid oedema, foreign body sensation in eye, increased lacrimation, injection-site haemorrhage, injection-site pain, ocular hyperaemia, punctate keratitis, raised intra-ocular pressure, reduced visual acuity, blurred vision, retinal degeneration, retinal pigment epithelium detachment, retinal pigment epithelium tear, vitreous detachment, vitreous floaters, vitreous haemorrhage. Rare: Hypopyon, vitritis, retinal detachment, retinal tear, uveitis