FANSIMEF
MEFLOQUINE, SULFADOXINE AND PYRIMETHAMINE · by ROCHE
Composition
Tab: Mefloquine NCI 50 mg, sulfadoxine 50 mg, pyrimethamine 25 mg.
Indications & Dosage
Therapy of plasmodium falciparum malaria resistant to other antimalarial agents: Adults: Non-immune patients: Single dose of 3 tab. Semi-immune patients: 60 kg or less body-weight: AZ Single dose of 2 tab, more than 60 kgbody-weight: single dose of 3 tablets. Children: Single dose of 1/2 to 2 tabs according to age.
Contraindications
Sulphonamide hypersensitivity.
Precautions
Impaired renal or hepatic function, porphyria, psoriasis,severe gastrointestinal, neurological or blood disorders, infants up to two months.
Interactions
Folate inhibitors.
Pregnancy
: Contraindicated
Lactation
Contraindicated
Side Effects
Abdominal cramp, blood dyscrasias, GI distress, nausea, vomiting, weakness, diarrhoea, muscular cramp, malaise, irregular heartbeat, skin-pigmentation, hair loss, tinnitus, lumpus erythematosus, corneal opacities, retinal damage, blood disorders,headache, skin reactions and liver cell damage.