FLUCLOX
FLUCLOXACILLIN · by STALLION
Composition
Cap 250 mg/500 mg: Flucloxacillin 250 mg/500 mg. Inj 250 mg/500 mg: Flucloxacillin 250 mg/ 500 mg; vial. Syp: Per 5 ml: Flucloxacillin 125 mg.
Indications & Dosage
Infections due to beta-lactamase-producing staphylococci including respiratory tract, ENT, UT and soft tissue infections, Gonorrhoea, dental abscess, otitis externa, Adjunct in pneumonia, impetigo and cellulitis: ORAL: Adult: 250-500 mg 4 times a day; Children 1 month-1 year: 62.5-125 mg 4 times a day; 2-9 years: 125-250 mg 4 times a day; 10-17 years: 250-500 mg 4 times a day. BY IM INJ: Adult: 250-500 mg every 6 hours BY SLOW IV INJ, ORIV INF: Adult: 0.25-2 g every 6 hours. Endocarditis (in combination): BY SLOW IV INJ, ORIV INF: Adult: (body-weight up to 85 kg): 8 g daily in 4 divided doses; (body-weight 85 kg and above): 12 g daily in6 divided doses. Osteomyelitis: BY SLOW IV INJ, ORIV INF: Adult:Up to 8 g daily in 3-4 divided doses. Surgical prophylaxis: BY SLOW IV INJ, OR IV INF: Adult: 1-2 g, to be administered up to 30 minutes before the procedure, then (by mouth or by IM injection or by slow IV injection or by IV INF) 500 mg every 6 hours if required for up to 4 further doses in high risk procedures. Staphylococcal lung infection in cystic fibrosis: ORAL: Child: 25 mg/kg 4 times a day (max. per dose 1 g), alternatively 100 mg/kg daily in 3 divided doses; max. 4 g per day.
Administration
Intermittent in glucose 5% or sodium chloride 0.9%. Suggested volume 100 ml given over 30-60 min, Viadrip tubing in glucose 5% or sodium chloride 0.9% or ringers solution or compound sodium lactate. Continuous infusionnot usually recommended.
Contraindications
History of flucloxacillin associated jaundice/hepatic dysfunction, hypersensitivity to penicillins, cephalosporins or other beta-lactams.
Precautions
Hepatic impairment, severe renal impairment; monitor renal and hepatic function during prolonged treatment, age above 50 years, serious underlying disease.
Interactions
Probenecid.
Pregnancy
Use only if essential
Lactation
Caution advised
Side Effects
: Hypersensitivity reactions, GI disturbane, super infection,hepatic reactions. Rare: Pseudomembranous Colitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.