Composition
Tab 100 mg/175 mg/200 mg/250 mg/300 mg/350 mg/400 mg/600 mg: Theophylline 100 mg/175 mg/200 mg/250 mg/300 mg/350 mg/400 mg/600 mg.Cap 100 mg/200 mg/300 mg: Theophylline 100 mg/200 mg/300 mg.S
Indications & Dosage
Reversible airways obstruction, Severe acute asthma, Chronic asthma: Adults & Children above 12 yrs: 175 mg-350 mg twice daily. Children 2-6 yr: 60-120 mg twice daily; 6-12 yr: 125-250 mg twice daily.
Contraindications
Acute porphyria, epilepsy, concomitant use of ephedrine in children.
Precautions
CNS disorder, cardiac arrhythmia, other cardiovascular disease, risk of hypokalaemia, peptic ulcer, hyperthyroidism, hypertension, history of seizures, hepatic dysfunction, acute febrile illness, chronic alcoholism, elderly.
Interactions
Plasma levels increased by allopurinol, cimetidine, ciprofloxacin, clarithromycin, diltiazem, disulfiram, erythromycin, fluconazole, ketoconazole, fluvoxamine, influenza vaccine, interferon, methotrexate, mexilefine, nizatidine, quinolones, pentoxyfylline, propafenone, propranolol, verapamil. Plasma levels decreased by carbamazepine, primidone, phenytoin, rifampicin, ritonavir, sulfinpyrazone, barbiturates, smoking, St. Johns Wort. Other interactions: beta-agonists, adenosine, benzodiazepines, diuretics, ketamine, halothane, lithium, corticosteroids.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
CNS stimulation, arrhythmias, headache, convulsions, diarrhoea, gastric irritation, insomnia, nausea, palpitation, tachycardia, vomiting, GI upset, hypotension.