TICACLAV
TICARCILLIN AND CLAVULANIC ACID · by STALLION
Composition
Infusion 3.2 gm: Clavulanic acid 200 mg (as potassium salt), ticarcillin 3 gm (as sodium salt); powder for infusion vial
Indications & Dosage
Infections due to Pseudomonas and Proteus species: BY IV INF: Adult: 3.2 g every 6-8 hours; increased if necessary to3.2 g every 4 hours, for more severe infections. Children: 80 mg/kg six to eight hourly; neonates, 80 mg/kg 12 hourly, children above 40 kg same as adult dose. Septicaemia, Bone infection: BY IV INF: Adults: 200-300 mg/kg/day ticarcillin given every 4-6 hr. Children 3 month less than 60 kg body weight: 50 mg/kg/day ticarcillin given every 4 hr; above 60 kg body weight: 3.2 gm every 4-6 hr.
Administration
Infuse over 30 min. Administer 1 hour apart from aminoglycosides. Give around-the-clock. Reconstituted solution is stable for 6 hours at room temperature & 72 hours when refrigerated, IV infusion in NS is stable for 24 hours at room temperature, 7 days when refrigerated, or 30 days when frozen. Darkening of solution indicates loss of potency of clavulanate potassium.
Contraindications
Hypersensitivity to penicillins, cephalosporins or other beta-lactams.
Precautions
Severe hepatic dysfunction, moderate or severe renal impairment.
Interactions
Probenecid.
Pregnancy
No evidence of harm
Lactation
Caution advised
Side Effects
GI disturbances, nausea, vomiting, constipation, dyspepsia, headache, hypersensitivity, GI upset. Rarely, hepatitis, cholestatic jaundice, haematological and CNS effects, hypokalaemia, pseudomembranous colitis